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Reticulocyte Binding Protein Homologue 5 is a target of balancing selection in the <i>Plasmodium falciparum</i> population of Papua New Guinea.

Naung MT, Martin E, Wong W, Razook Z, Utama D, Guy AJ, Harrison ST, Cowman AF, Lin E, Kiniboro B, Laman M, Mueller I, Barry AE

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  • Journal Frontiers in parasitology

  • Published 22 Dec 2023

  • Volume 2

  • Pagination 1288867

  • DOI 10.3389/fpara.2023.1288867

Abstract

population, immune escape was not observed within the cohort of young children. Limited immunity and therefore low selective pressure may explain this result, alternatively other evolutionary forces may contribute to balancing selection at the RH5-BSG binding interface in PNG.